Pinealon Neuroprotective Bioregulator Research
Pinealon neuroprotective bioregulator research — Khavinson short peptide bioregulators, pineal gland regulation, circadian rhythm modulation, thymic function, immune restoration, and longevity science.
Featured Research
In-depth research profiles with mechanisms of action, key findings, and peer-reviewed citations.
Epithalon (Epitalon)
Also known as: Epithalon, Epithalone, Ala-Glu-Asp-Gly
Epitalon is a synthetic tetrapeptide based on the naturally occurring peptide epithalamin, which is extracted from the pineal gland. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, epitalon is the most extensively studied of the Khavinson peptide bioregulators. Its primary mechanism of action involves activation of telomerase, the enzyme ...
Quick Facts
Sequence: Ala-Glu-Asp-Gly
MW: 390.35 g/mol
CAS: 307297-39-8
Store lyophilized powder at -20C. Reconstituted solution should be refrigerated at 2-8C. As a small tetrapeptide, epital...
Thymalin
Also known as: Thymalin, Thymic Factor, Thymus Extract Peptide
Thymalin is a polypeptide preparation originally isolated from calf thymus glands, developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. It consists of a complex of small peptides that have been studied extensively in Russian clinical practice for immunomodulatory and geroprotective properties. The primary bioactive component is believed t...
Quick Facts
Sequence: Complex of thymic peptide bioregulators (Glu-Trp primary com...
MW: Variable (peptide complex)
CAS: N/A (complex extract)
Store lyophilized powder at -20C. Reconstituted solution should be refrigerated at 2-8C and used within 10 days. Protect...
Latest Research Articles
Deep-dive articles from the System Peptides Research Network.
Epitalon: Telomerase Activation and Longevity Research
Research review of Epitalon (Epithalon) — the synthetic tetrapeptide studied for telomerase activation, pineal gland fun...
Read Article Category RoundupEssential Peptides for Anti-Aging and Longevity Research
The most studied peptides in aging research — Epitalon, NAD+, MOTS-c, GHK-Cu, and SS-31. Mechanisms, evidence levels, an...
Read Article Research ScienceThe SIRT1-NAD+ Axis: A Key Target in Peptide Longevity Research
How the SIRT1-NAD+ signaling axis connects cellular energy, aging, and peptide interventions like NAD+ supplementation a...
Read ArticleResearch Applications
Key research categories and applications studied in the scientific literature.
Cognitive Enhancement
Pinealon promotes neuroprotection and acts as a mitochondrial booster to combat age-related cognitive decline through direct peptide-DNA interactions at the regulatory level.
Sleep Optimization
Supports the central nervous system to reduce mental fatigue and improve sleep quality by acting on the brain's pineal regulatory systems and circadian clock mechanisms.
Anti-Aging & Longevity
Khavinson bioregulators including Pinealon and Thymalin increased both mean and maximum lifespan in rodent studies — proposed mechanism involves tissue-specific gene regulation restoration.
Immune Support
Thymalin enhances T-cell production and activity, aiding in defense against viral infections and supporting immune balance — targeting the age-related decline of thymic function.
Frequently Asked Questions
Common questions about pinealon research research, purity standards, and sourcing.
What is Pinealon?
Pinealon (Glu-Asp-Arg) is a synthetic tripeptide bioregulator developed by the Khavinson group at the St. Petersburg Institute of Bioregulation and Gerontology. It is designed to regulate pineal gland and central nervous system function through direct peptide-DNA interactions.
What are Khavinson bioregulators?
Khavinson bioregulators are short peptides (2-4 amino acids) hypothesized to interact directly with DNA at the promoter level, modulating gene expression in specific tissues. They represent a class of regulatory molecules distinct from classical receptor-binding peptides.
How do bioregulators relate to longevity research?
In multiple rodent lifespan studies, Khavinson bioregulators (including Epitalon for the pineal gland and Thymalin for the thymus) increased both mean and maximum lifespan. The proposed mechanism involves restoration of age-related organ function decline through tissue-specific gene regulation.
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